Home Black Seeds How to reverse Systemic lupus erythematosus (SLE)

How to reverse Systemic lupus erythematosus (SLE)

by Sean Martu

Lupus is an autoimmune disease in which your immune system damages your body’s organs and tissue. It causes inflammation that can affect your skin, joints, blood, and organs(exp. kidneys, lungs, and heart). 90% of all lupus patients are women, affecting women between the ages of 15–45. Women of “childbearing age” are by far the most likely to develop lupus. Also Being of African-American, Asian, or Native American descent are two to three times more likely than Caucasians to develop lupus. Eating a poor diet lacking nutrient deficiencies also contributed to lupus.


Lupus is a condition that causes system-wide inflammation. As an autoimmune disease, instead of protecting your body your immune system. You may experience symptoms throughout your body depending on where your autoimmune system damages tissue, including in your: Skin, Blood, Joints, Kidneys, Brain, Heart, and Lungs etc.

How to Reverse Lupus

Nigella Sativa

According to the research article “Effect Nigella sativa extract for balancing immune response in
pristane induced lupus mice modelNigella sativa (NS) has anti-inflammatory and immunomodulatory effects and thus has the potential to improve SLE symptoms.

The article states –

Induction of lupus
A total of 20 BALB/c mice were injected with pristane
(Sigma-Aldrich, Saint Louis, MO) intraperitoneally at a dose of
0.5 ml (concentration of 782 µg/ml). Sixteen weeks after injection,
clinical manifestations of lupus were observed in the mice. The
treatment was given after clinical findings of lupus.


Extraction of NS
The seeds of NS were mashed and then extracted with
ethanol solvent using the soxhletation method. The resulting
mixture was vortexed for 1 minute and sonified for 20 minutes.
After that, it was incubated with ethanol solution for 24 hours in
a constant Rotamix and Soxhlet machine, then revortexed for 1
minute, and centrifuged for 25 minutes at 1,400 rpm.

The article concludes-

In conclusion, there is a relation between the increase
of NS extract dose with the decrease of anti-dsDNA level and the
increase of Treg percentage. The most effective NS dose in this
research is 4.8 g/kgBW/day. NS has the potential to be an adjuvant
therapy for SLE.

You can get powdered Nigella Sativa on my website.

Vitamin D

The research article “Restoration of regulatory and effector T cell balance and B cell homeostasis in
systemic lupus erythematosus patients through vitamin D supplementation” states –

Methods: In this prospective study, we evaluated the safety and the immunological effects of
vitamin D supplementation (100 000 IU of cholecalciferol per week for 4 weeks, followed by
100 000 IU of cholecalciferol per month for 6 months.) in 20 SLE patients with
hypovitaminosis D.


Results: Serum 25(OH)D levels dramatically increased under vitamin D supplementation
from 18.7±6.7 at day 0 to 51.4±14.1 (p<0.001) at 2 months and 41.5±10.1 ng/mL (p<0.001) at
6 months. Vitamin D was well tolerated and induced a preferential increase of naïve CD4+
cells, an increase of regulatory T cells and a decrease of effector Th1 and Th17 cells. Vitamin
D also induced a decrease of memory B cells and anti-DNA antibodies. No modification of
the prednisone dosage or initiation of new immunosuppressant agents was needed in all
patients. We did not observe SLE flare during the 6 months follow-up period.


Conclusions: This preliminary study suggests the beneficial role of vitamin D in SLE patients
and needs to be confirmed in randomized controlled trials.

It states in the research article “Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity” –

Results: Presence of CLE raised the odds of having vitamin D deficiency (OR 3.47, 95% CI 1.79-6.69). Increasing age and disease duration were associated with higher odds of having vitamin D deficiency. After a one-year follow-up, disease activity improved in the treatment group (CLASI A 2.7 ± 2.9 vs. 0.9 ± 1.4) (p = 0.003), as confirmed by the patient assessment (p = 0.01).


Conclusions: Vitamin D inadequacy is more prevalent in CLE participants than in healthy controls. Treating vitamin D insufficiency is associated with improved disease severity according to physician and patient assessments.

In the above-referenced article, “They were placed in the following oral vitamin D supplementation schedule: 1400 IU of cholecalciferol, plus 1250 mg of calcium carbonate, per day for 40 days, followed by a tablet twice a day of a fixed combination of 1250 mg of calcium carbonate and 400 IU of cholecalciferol for one year of treatment.

You can get a Drs Best 5000IU D3 per pill on Amazon.


A study discovered that people with fibromyalgia, chronic fatigue syndrome, and SLE have a greater lack of magnesium compared to those without these conditions. This study was not conducted in a large population of people with lupus. Another larger study showed that individuals with SLE who are deficient in magnesium are at a higher risk for infection. In a group of 476 people diagnosed with SLE, those who had a current infection were more likely to have a lower magnesium level than those without an infection. As of yet, magnesium supplements have not been directly tested to treat lupus.

My Conclusion

Although there is research for the alleviation/reversal of lupus utilizing Black seeds(nigella sativa) or high dosages of Vitamin D3, I would use both simultaneously. Coincidently, you would also have to take magnesium, as it’s useless to take vitamin D3 without magnesium. For your body to convert Vitamin D3 to its hormonal form, it needs magnesium to do that process. Read my article on magnesium, as you must take a bioavailable form for it to be utilized in your body.



Necessary internet disclaimer:  All information and resources found on Nothingsincurable.com are based on the opinions of the author unless otherwise noted. I am not a doctor nor do I have any medical training, all information is intended to motivate readers to make their own nutrition and health decisions after consulting with their health care provider. The author of this site encourages you to consult a doctor before making any health changes, especially any changes related to a specific diagnosis or condition.

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